Key result
Administering vaccines to pediatric solid-organ transplant candidates earlier and more rapidly than in healthy children improves vaccination rates without compromising immunogenicity.
Early and rapid administration of vaccines to pediatric solid-organ transplant candidates is recommended to prevent post-transplantation complications from vaccine-preventable illnesses.
May support accelerated vaccination schedules in pediatric transplant candidates; leaves open need for prospective trials before practice change.
Many children who receive solid-organ transplants have not completed their primary immunizations prior to transplantation. This leaves pediatric transplant recipients susceptible to the vaccine preventable illness of childhood, which if acquired post-transplantation are associated with increased rates of complications, hospitalization, graft rejection and mortality. The administration of vaccines to transplant candidates earlier and more rapidly than in the healthy child will improve vaccination rates among transplant recipients while not compromising immunogenicity. The recommended vaccines and vaccine schedule are discussed in detail.
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Campbell et al. (2005) conducted a review in Pediatric solid-organ transplantation candidates. Immunization was evaluated. Administering vaccines to pediatric solid-organ transplant candidates earlier and more rapidly than in healthy children improves vaccination rates without compromising immunogenicity.
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