Key result
Transverse aortic constriction induced exacerbated gut inflammation, dysbiosis, and leakage in IL-10 knockout mice, linking heart failure inflammatory signaling to multi-organ damage.
Hypertrophic heart failure induced by transverse aortic constriction promotes gut dysbiosis and leakage in IL-10-deficient mice, suggesting a link between heart failure inflammatory signaling and multi-organ damage.
IL-10, crucial for systemic inflammation regulation and gut mucosal homeostasis, was investigated using IL-10 knockout (KO) mice. Exacerbated gut inflammation was observed post-transverse aortic constriction (TAC) in IL-10-depleted mice, whereas wild-type (WT) mice showed reduced IL-10 gene expression in colon and ileum. TAC induced gut dysbiosis and leakage in IL-10 KO mice, suggesting a link between enhanced inflammatory signaling in heart failure and multi-organ damage via gut dysbiosis and leakage.
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Ranjan et al. (2025) studied Hypertrophic heart failure. Transverse aortic constriction (TAC) and IL-10 deficiency vs. Wild-type (WT) mice was evaluated on Gut inflammation, dysbiosis, and leakage. Transverse aortic constriction induced exacerbated gut inflammation, dysbiosis, and leakage in IL-10 knockout mice, linking heart failure inflammatory signaling to multi-organ damage.
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