Why the study?
Does glycopyrrolate mixed with neostigmine safely and effectively reverse non-depolarising neuromuscular block compared to atropine mixed with neostigmine in children?
Does glycopyrrolate mixed with neostigmine safely and effectively reverse non-depolarising neuromuscular block compared to atropine mixed with neostigmine in children?
Glycopyrrolate is a safe and effective alternative to atropine for reversing non-depolarising neuromuscular block in children, though it offers fewer advantages than in adults.
Glycopyrrolate may be safe for pediatric neuromuscular reversal; leaves open whether advantages justify routine use over atropine.
Atropine and glycopyrrolate were compared when given in a mixture with neostigmine for the reversal of non-depolarising neuromuscular block in children. Glycopyrrolate was an effective antimuscarinic agent and could be safely used as an alternative to atropine, although the advantages in this age group were not as marked as have been observed in adults.
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BLACK et al. (1980) studied this question.
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