Why the study?
Does glycopyrrolate improve heart rate stability and reduce arrhythmias compared to atropine during reversal of nondepolarizing neuromuscular block with neostigmine?
Does glycopyrrolate improve heart rate stability and reduce arrhythmias compared to atropine during reversal of nondepolarizing neuromuscular block with neostigmine?
Glycopyrrolate is superior to atropine for preventing neostigmine-induced bradycardia and reducing secretions during reversal of neuromuscular blockade.
May favor glycopyrrolate over atropine for neostigmine reversal; leaves open confirmation in contemporary RCTs.
Glycopyrrolate and atropine were compared as to their effects on heart rate, arrhythmias, blood pressure, and volume of oropharyngeal secretions. Glycopyrrolate protects against neostigmine-induced bradycardia, produces less initial tachycardia, causes a lower incidence of cardiac arrhythmias, and is a superior oropharyngeal drying agent. Use of this drug instead of atropine should be considered during reversal of nondepolarizing neuromuscular block.
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Gerard W. Ostheimer (1977) studied this question.
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