Key result
Administration of dexmedetomidine after congenital cardiac surgery decreased pulmonary artery pressure from 30 mm Hg at baseline to 24 mm Hg at 6 minutes and 26 mm Hg at 1 hour (p < 0.001).
Why the study?
Does dexmedetomidine reduce pulmonary artery pressure in pediatric patients after congenital cardiac surgery?
Observational (n=22)
No
Does dexmedetomidine reduce pulmonary artery pressure in pediatric patients after congenital cardiac surgery?
Effect estimate: decreased from 30 mm Hg to 24 mm Hg at T1 and 26 mm Hg at T2
p-value: p=<.001
Dexmedetomidine administration after congenital cardiac surgery does not increase pulmonary artery pressure and is associated with a significant decrease in pulmonary pressures.
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Associated with reduced pulmonary artery pressure after pediatric congenital cardiac surgery; hypothesis-generating and requires randomized confirmation before practice change.
Lazol et al. (2010) conducted an observational in congenital cardiac surgery (n=22). dexmedetomidine vs. baseline was evaluated on pulmonary artery pressure (decreased from 30 mm Hg to 24 mm Hg at T1 and 26 mm Hg at T2, p=<.001). Administration of dexmedetomidine after congenital cardiac surgery decreased pulmonary artery pressure from 30 mm Hg at baseline to 24 mm Hg at 6 minutes and 26 mm Hg at 1 hour (p < 0.001).
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