Phylogenetic approach to endocrine-immune system interactions

The survival of organisms in a hostile and highly variable environment is dependent upon the proper balance of physiological processes. According to emerging views, homeostasis may be achieved by the coordinated activities of the three major integrative systems: the nervous, endocrine, and immune systems. Although each of these systems is replete with its particular molecules, cells, tissues, and organs, often not seemingly integrated into the whole organism, homeostasis is uncompromised and the three systems function properly. This mini-review contains the essence of newer approaches which emphasize those which are being developed in our laboratory. Our model is concerned with the regulation of the immune system by the brain in fish.