Key result
Paroxysmal atrial fibrillation without coexistent cardiovascular disease was associated with significantly reduced left ventricular peak systolic circumferential strain (-18.2% vs -21.9%, p<0.001) and elevated native T1 times, which correlated with increased levels of C-reactive protein and sST2.
Why the study?
CMR feature tracking has not yet been applied to quantify early LV myocardial strain and T1 mapping in patients with paroxysmal AF without coexistent cardiovascular disease.
Population
80 paroxysmal AF patients without coexistent cardiovascular disease and 20 age- and sex-matched healthy controls
Comparison
Paroxysmal AF patients vs healthy controls
Design
Case-control study
Authors
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Suggests inflammation contributes to early LV impairment in paroxysmal AF; hypothesis-generating and requires prospective validation.
Observational (n=100)
No
Absolute Event Rate: -18.2% vs -21.9%
p-value: p=<0.001
In patients with paroxysmal AF without other cardiovascular diseases, CMR detects early LV myocardial abnormalities that correlate with biomarkers of inflammation and myocardial stiffness.
Zhao et al. (2021) conducted an observational in Paroxysmal atrial fibrillation (n=100). Paroxysmal atrial fibrillation vs. Healthy controls was evaluated on Left ventricular peak systolic circumferential strain (%) (p=<0.001). Paroxysmal atrial fibrillation without coexistent cardiovascular disease was associated with significantly reduced left ventricular peak systolic circumferential strain (-18.2% vs -21.9%, p<0.001) and elevated native T1 times, which correlated with increased levels of C-reactive protein and sST2.
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