Key result
Soybean-derived peptide LSW improved endothelial function and antagonized Angiotensin II-induced damage by repairing miRNA expression in vascular smooth muscle cell-derived extracellular vesicles.
Why the study?
Vascular cells transfer biological cargo via extracellular vesicles, but the effects of vesicles from vascular smooth muscle cells exposed to angiotensin II or LSW on endothelial cells remained to be explored.
Does the soybean-derived peptide LSW protect vascular endothelial cells from Angiotensin II-induced damage via extracellular vesicles?
Does the soybean-derived peptide LSW protect vascular endothelial cells from Angiotensin II-induced damage via extracellular vesicles?
The soybean-derived peptide LSW protects vascular endothelial cells from Angiotensin II-induced injury by modulating miRNA expression in extracellular vesicles derived from vascular smooth muscle cells.
LSW-modulated EVs may dampen endothelial inflammation in vitro; leaves open any in vivo or clinical vascular effects.
An emerging inference is that vascular cells transfer their biological cargo to recipient cells by secretion of extracellular vesicles (EVs). This study explored the effects of EVs produced from VSMCs with Ang II (EVs-A) or LSW + Ang II on HUVECs. The EVs-A increase ROS production, activate inflammation, and upregulate the expression of adhesion molecules. Among the EVs-A, miR-22, miR-143, miR-144, and miR-155 were significantly downregulated, while VSMCs pre-incubated with LSW could produce improved EVs. RNA sequencing revealed differential expression of genes associated with endothelial dysfunction, including the TNF signaling pathway, NOD-like receptor signaling pathway, NF-κB signaling pathway, and fluid shear stress and atherosclerosis pathway. Finally, we found that LSW could improve endothelial function by repairing the expression of miRNAs in VSMCs. It also suggests a potential mechanism for the injury action of endogenous peptide Ang II and protective effects of exogenous peptide LSW on vascular endothelial cells.
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Song et al. (2021) studied Endothelial dysfunction. Soybean-derived antihypertensive peptide LSW (Leu-Ser-Trp) vs. Angiotensin II alone was evaluated on Endothelial function, ROS production, inflammation, and miRNA expression. Soybean-derived peptide LSW improved endothelial function and antagonized Angiotensin II-induced damage by repairing miRNA expression in vascular smooth muscle cell-derived extracellular vesicles.
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