Key result
Exosomes from adventitial fibroblasts of spontaneously hypertensive rats transfer ACE to vascular smooth muscle cells, increasing Ang II levels and promoting cell migration.
Population
Primary vascular smooth muscle cells and adventitial fibroblasts obtained from the aorta of spontaneously…
Comparison
Adventitial fibroblast exosomes from SHR, with… vs AFE from WKY rats or untreated controls.
Design
Preclinical
Authors
Loading...
May implicate exosome-mediated ACE transfer in vascular remodeling; hypothesis-generating and requires human validation before clinical relevance.
Exosomes from adventitial fibroblasts of spontaneously hypertensive rats transfer ACE to vascular smooth muscle cells, promoting their migration via Ang II and AT1R activation.
Tong et al. (2018) studied Hypertension. Adventitial fibroblast exosomes from spontaneously hypertensive rats vs. Adventitial fibroblast exosomes from Wistar-Kyoto rats was evaluated on Vascular smooth muscle cell migration. Exosomes from adventitial fibroblasts of spontaneously hypertensive rats transfer ACE to vascular smooth muscle cells, increasing Ang II levels and promoting cell migration.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: