Key result
Vascular adventitial fibroblasts from spontaneously hypertensive rats exhibited significantly greater migration in response to Angiotensin II compared to those from normotensive Wistar-Kyoto rats.
Population
Vascular adventitial fibroblasts isolated from the thoracic aortae of 8-week-old male spontaneously…
Comparison
Angiotensin II and other stimulants with or… vs Untreated cells and WKY-AFs.
Design
Preclinical
Authors
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May implicate adventitial fibroblasts in hypertensive remodeling; leaves open whether migration pathways are viable therapeutic targets.
p-value: p=<0.05
Vascular adventitial fibroblasts from spontaneously hypertensive rats exhibit increased migratory capacity mediated by Ang II via AT1-R, ERK1/2, and p38 MAPK pathways, suggesting a role in hypertensive vascular remodeling.
Li et al. (2006) studied Hypertension. Angiotensin II vs. Untreated cells and WKY-AFs was evaluated on Cell migration (fold increase) (p=<0.05). Vascular adventitial fibroblasts from spontaneously hypertensive rats exhibited significantly greater migration in response to Angiotensin II compared to those from normotensive Wistar-Kyoto rats.
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