Key result
Angiotensin II stimulates aortic adventitial fibroblasts to recruit monocytes via MCP-1, which in turn activate fibroblast proliferation and adventitial thickening in a positive feedback loop.
Population
Primary human aortic adventitial fibroblasts (AoAF) and THP-1 monocytes in vitro; CCR2-null mice in vivo
Comparison
Angiotensin II stimulation and CCR2 wild-type… vs Unstimulated cells and Ang II-treated CCR2 mice…
Design
Preclinical
Authors
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May implicate MCP-1 in Ang II-driven adventitial remodeling; hypothesis-generating for human vascular disease.
A fibroblast-monocyte amplification loop mediated by MCP-1 plays a critical role in Ang II-induced adventitial inflammation and vascular remodeling.
Tieu et al. (2010) studied Angiotensin II-induced aortic inflammation and adventitial expansion. Angiotensin II stimulation was evaluated on Fibroblast proliferation, adventitial thickening, and cytokine production. Angiotensin II stimulates aortic adventitial fibroblasts to recruit monocytes via MCP-1, which in turn activate fibroblast proliferation and adventitial thickening in a positive feedback loop.
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