Key result
Visceral obesity in patients with acquired mitral valve disease was associated with more impaired left ventricular global longitudinal strain (-15.65% vs -19.4%; p=0.020).
Why the study?
The relationship between epicardial or visceral obesity and cardiac remodeling characteristics in patients with acquired mitral valve disease undergoing surgical treatment needed to be evaluated.
Is visceral obesity associated with worse myocardial remodeling and atrial fibrillation in patients with acquired mitral valve disease?
Observational (n=49)
Is visceral obesity associated with worse myocardial remodeling and atrial fibrillation in patients with acquired mitral valve disease?
In patients with acquired mitral valve disease requiring surgery, visceral and epicardial obesity are associated with worse biventricular structural and functional impairment and a higher likelihood of atrial fibrillation.
May warrant visceral fat assessment in MV surgery candidates; leaves open causal links and intervention effects on remodeling.
Aim. To study the relationship between epicardial/visceral obesity and cardiac remodeling characteristics in patients with acquired mitral valve (MV) disease and indications for surgical treatment of the defect. Material and methods. The study included 49 patients hospitalized for surgery of non-infectious acquired MV defect. Patients were divided into groups according to computed tomography as follows: group 1 — with visceral obesity (visceral adipose tissue ≥130 cm 2 (n=28)), and group 2 — without visceral obesity (n=21). Results. Patients with visceral obesity had more impaired left ventricular (LV) global longitudinal strain compared to the group without visceral obesity (-15,65 [-18,8; -11,6] vs -19,4 [-21,3; -16,9]%, p=0,020). Right ventricular ejection fraction (3D echocardiography) in group 1 was lower compared to patients in group 2 as follows: median 46 [40,6; 48,9] vs 53 [45,8; 54,2]% (p=0,042). Increase in epicardial adipose tissue (EAT) volume by 1 cm 3 according to multislice computed tomography was associated with left atrial increase by a B-coefficient of 0,009 (p=0,001) and LV end-systolic volume by a B-coefficient of 0,1224 (p=0,046). The visceral adipose tissue/subcutaneous adipose tissue index >0,4 is associated with an increase in the LV mass index by a B-coefficient of 44,7 (p=0,001). According to the ROC analysis, the EAT volume >115,1 cm 3 is associated with arrhythmias such as atrial fibrillation (AUC=0,714 (p=0,003)). Conclusion. Visceral obesity is associated with a more pronounced structural and functional impairment of heart ventricles, while EAT volume >115,1 cm 3 — with atrial fibrillation before MV defect surgery.
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Dren’ et al. (2025) conducted an observational in acquired mitral valve disease (n=49). Visceral obesity vs. No visceral obesity was evaluated on Left ventricular global longitudinal strain (p=0.020). Visceral obesity in patients with acquired mitral valve disease was associated with more impaired left ventricular global longitudinal strain (-15.65% vs -19.4%; p=0.020).
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