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A homochiral sulfoxide‐directed reductive deoxygenation of 2‐( p ‐tolylsulfinyl)methyl‐2‐chromanols allows the stereoselective formation of 2 H ‐chromans with up to 95:5 diastereoisomeric ratio. This new methodology was appliedin a short and convergent enantioselective synthesis ofthe ( S , R , R , R )‐enantiomer of the antihypertensive drugNebivolol.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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Carreño et al. (2008) studied this question.
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