Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study
Key result
Impaired glucose metabolism and Type 2 diabetes were associated with a higher prevalence of depressive symptoms in women (OR 3.60 and 3.18, respectively) but not in men.
Why the study?
Is impaired glucose metabolism or Type 2 diabetes associated with an increased prevalence of depressive symptoms in a general population cohort?
Population
550 residents of the Hoorn region, the Netherlands, with normal glucose metabolism, impaired glucose…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
May warrant depression screening consideration in women with dysglycemia; leaves open causality and sex-specific mechanisms.
Study Design
Type
Cross-Sectional (n=550)
Structured PICO
Is impaired glucose metabolism or Type 2 diabetes associated with an increased prevalence of depressive symptoms in a general population cohort?
P
Population
550 residents (276 men and 274 women) of the Hoorn region, the Netherlands, assessed for depressive symptoms across different glucose metabolism statuses.
C
Comparator
Normal glucose metabolism (NGM)
O
Outcome
Prevalence of depressive symptoms (measured using the Centre for Epidemiologic Studies Depression Scale, CES-D score >= 16)patient reported
Main Result
Odds Ratio: 3.6 (95% CI 1.57–8.28)
Absolute Event Rate: 23.1% vs 7.7%
p-value: p=<0.01
Depressive symptoms are significantly more common in women with impaired glucose metabolism or Type 2 diabetes compared to those with normal glucose metabolism, an association partially attenuated by cardiovascular risk factors.
Cite This Study
Adriaanse et al. (2008) conducted a cross-sectional in Impaired glucose metabolism or Type 2 diabetes mellitus (n=550). Impaired glucose metabolism or Type 2 diabetes mellitus vs. Normal glucose metabolism was evaluated on Depressive symptoms (CES-D score ≥ 16) (OR 3.60, 95% CI 1.57 to 8.28, p=<0.01). Impaired glucose metabolism and Type 2 diabetes were associated with a higher prevalence of depressive symptoms in women (OR 3.60 and 3.18, respectively) but not in men.