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A palladium(II)‐catalyzed protocol for the highly regioselective remote γ‐C–H arylation of aliphatic carboxylic acid has been disclosed. The 8‐aminoquinoline moiety as an intramolecular bidentate chelator was found to be suitable for this γ‐C–H arylation. Various aryl iodides successfully produced the regioselectively mono‐arylated products with negligible diarylation. Functional group tolerance and easy‐to‐handle reaction conditions make this method attractive. magnified image
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Dey et al. (2017) studied this question.
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