Why the study?
Does aspirin 325 mg every other day reduce the incidence of colorectal cancer in healthy male physicians?
Population
22,071 healthy male physicians aged 40 to 84 years in 1982 in the United States.
Comparison
Aspirin 325 mg every other day. vs Placebo.
Design
RCT, randomly assigned
Follow-up
12 years
Authors
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No benefit of alternate-day aspirin for colorectal cancer prevention in healthy male physicians; confirms null effect in primary prevention.
Does aspirin 325 mg every other day reduce the incidence of colorectal cancer in healthy male physicians?
Low-dose aspirin (325 mg every other day) does not reduce the incidence of colorectal cancer in healthy male physicians over 12 years of follow-up.
Til Stürmer (1998) studied this question.
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