Why the study?
How long should a trial of fluoxetine 20 mg/day continue before declaring nonresponse in patients with major depression?
Population
840 patients with major depression
Comparison
Fluoxetine 20 mg/day for 12 weeks vs Placebo (during weeks 13-26 discontinuation study)
Design
RCT, blinded
Follow-up
26 weeks
Authors
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Supports continuing fluoxetine trials to at least 8 weeks before declaring nonresponse in major depression; extends RCT evidence on delayed remission timing.
How long should a trial of fluoxetine 20 mg/day continue before declaring nonresponse in patients with major depression?
A trial of fluoxetine for major depression should continue for at least 8 weeks before declaring nonresponse.
Quitkin et al. (2003) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: