Two Functionally Redundant Sfp‐Type 4′‐Phosphopantetheinyl Transferases Differentially Activate Biosynthetic Pathways in Myxococcus xanthus

A liberal alliance. Two Sfp-type 4′-phosphopantetheinyl transferases (PPTases, MxPpt1 and MxPpt2) are encoded in the Myxococcus xanthus DK1622 genome. Disruption or over-expression led to significant changes in secondary metabolism, but production of known compounds was not abolished. Both PPTases thus apparently differ in their specificity for biosynthetic pathways by employing carrier proteins from polyketide synthases and nonribosomal peptide synthetases.