Key result
Early postnatal infection of newborn piglets with low and moderate virulence CSFV isolates resulted in persistent infection in 85% of animals, characterized by high viremia and a lack of specific humoral and cellular immune responses.
Population
20 piglets (two litters of 10 piglets each)
Design
Preclinical
Follow-up
6 weeks
Authors
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May complicate CSFV surveillance in swine herds; leaves open field validation before control implications.
The study provides the first evidence that classical swine fever virus can generate a postnatal persistent disease characterized by immunosuppression, which has implications for disease surveillance.
Muñoz‐González et al. (2015) studied Classical Swine Fever Virus (CSFV) infection (n=24). Classical Swine Fever Virus (CSFV) infection (PR or Cat01 strains) vs. Uninfected control pigs was evaluated on Viral persistence and immunological response. Early postnatal infection of newborn piglets with low and moderate virulence CSFV isolates resulted in persistent infection in 85% of animals, characterized by high viremia and a lack of specific humoral and cellular immune responses.
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