Key result
Contrast-associated acute kidney injury was associated with an increased risk of all-cause mortality in patients aged ≥75 years undergoing coronary angiography (HR 2.46; 95% CI 1.29-4.7; P=.006).
Why the study?
Older patients undergoing coronary angiography represent an increasing proportion, but data regarding the prognosis of geriatric contrast-associated acute kidney injury are limited.
Does contrast-associated acute kidney injury increase the risk of all-cause mortality in patients aged ≥75 years undergoing coronary angiography?
Cohort (n=571)
No
Does contrast-associated acute kidney injury increase the risk of all-cause mortality in patients aged ≥75 years undergoing coronary angiography?
Hazard Ratio: 2.46 (95% CI 1.29–4.7)
Absolute Event Rate: 22% vs 13.1%
p-value: p=.006
Contrast-associated acute kidney injury is a significant independent predictor of long-term mortality in patients over 75 years old undergoing coronary angiography.
CA-AKI signals higher mortality risk in elderly post-angiography patients; leaves open whether prevention alters outcomes in this growing population.
Older patients (≥75 years) after coronary angiography constitute an increasing proportion, but only limited data are available regarding the prognosis of geriatric contrast-associated acute kidney injury (CA-AKI). Patients (≥75 years) undergoing coronary angiography between December 2010 and September 2013 were consecutively enrolled. CA-AKI was defined as an increase in serum creatinine of 25% or .5 mg/dL from the baseline within 48-72 h of contrast exposure. All-cause mortality was assessed during median 7.5 years (interquartile range [IQR] 6.7-8.7 years) follow-up period. In total, 571 patients aged >75 years undergoing coronary angiography were enrolled in a single center study; 82 (14.4%) patients had CA-AKI. The all-cause mortality during the median 7.5 years follow-up period was 22.0% in patients with CA-AKI and 13.1% in patients without CA-AKI (P = .015). After adjusting for potential confounding factors, the multivariable analysis indicated that CA-AKI was related to an increased risk of all-cause mortality during the median 7.5-year follow-up (hazard ratio [HR]: 2.46; 95% CI: 1.29-4.7; P = .006). CA-AKI is a significant and independent predictor of long-term mortality for patients aged over 75 years who underwent coronary angiography.
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Guo et al. (2023) conducted a cohort in Coronary angiography (n=571). Contrast-associated acute kidney injury (CA-AKI) vs. No CA-AKI was evaluated on All-cause mortality (HR 2.46, 95% CI 1.29-4.7, p=.006). Contrast-associated acute kidney injury was associated with an increased risk of all-cause mortality in patients aged ≥75 years undergoing coronary angiography (HR 2.46; 95% CI 1.29-4.7; P=.006).
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