Two new compounds, 5-hydroxy-2- (1‘-oxo-5‘-methyl-4‘-hexenyl)benzofuran ( 1 ) and 5-hydroxy-2-(1‘-hydroxy-5‘-methyl-4‘-hexenyl)benzofuran ( 2 ), have been isolated via bioassay-directed fractionation of culture extracts of an unidentified endophytic fungus obtained from wintergreen, Gaultheria procumbens L. Their structures have been deduced from spectral data and confirmed by synthesis. Both 1 and 2 show toxicity to spruce budworm ( Christoneura fumiferana Clem.) cells, and 1 is also toxic to the larvae.
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Findlay et al. (1997) studied this question.
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