Evaluation of Diagnostic Accuracy of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3 in Growth Hormone-Deficient Children and Adults Using ROC Plot Analysis

158 subjects including 66 children (age 1.3-15 yr; 34 with growth hormone deficiency [GHD], 32 with idiopathic short stature) and 92 adults (age 18-70 yr; 72 with GHD [34 childhood onset, 38 adult onset], 20 healthy volunteers).

Diagnostic testing using IGF-I and IGF-binding protein-3 (IGFBP-3) standard deviation scores (SDS)

Idiopathic short stature (in children) and healthy volunteers (in adults)

Diagnostic accuracy (sensitivity, specificity, diagnostic efficiency) for growth hormone deficiencysurrogate