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Endothelial dysfunction and reduced nitric oxide synthesis are proposed as main mechanisms of left atrial thrombus formation based on a novel rat model.
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Endothelial dysfunction, particularly reduced nitric oxide synthesis, plays a crucial role in left atrial thrombus formation, providing a potential target for preventing thromboembolic events.
ent from that of the vascular wall, but the reduction of similar anticoagulation factors, including thrombomodulin, NO, and plasminogen activator, or upregulation of plasminogen activator inhibitor-1, has been documented in the LA wall in the elderly in whom a hypercoagulation state can be speculated. 4-6 Thus, endothelial dysfunction is probably involved, at least in part, in mechanism of thrombus formation in the LA. 7,8
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Shinichi Niwano (2014) conducted an editorial in Left atrial thrombus formation. Endothelial dysfunction and reduced nitric oxide synthesis are proposed as main mechanisms of left atrial thrombus formation based on a novel rat model.
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