Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease

doi:10.1080/0886022x.2021.1953529

January 1, 2021Renal FailureOpen Access

Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease

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Key Points

Investigate predictors of coronary artery calcification and evaluate its relationship with subsequent cardiovascular events in patients with stage 3–5 chronic kidney disease.
Enrolled 290 patients with stage 3–5 chronic kidney disease from 2018 to May 2019, evaluating coronary artery calcification via computed tomography.
Measured matrix Gla protein and interleukin-6 using enzyme-linked immunosorbent assay in a subset of 131 patients.
Tracked cardiovascular events in 276 patients, assessing predictors and outcomes using binary logistic regression and Cox proportional hazard modeling.
Coronary artery calcification was detected in 57.93% of patients and was associated with older age, diabetes, hyperphosphatemia, dialysis duration, neutrophil-lymphocyte ratio, and elevated interleukin-6.
Moderate to severe coronary artery calcification was correlated with a heightened risk of cardiovascular events (HR: 7.250; 95% CI: 3.192–16.470).
Higher matrix Gla protein levels protected against calcification and were associated with a lower risk of cardiovascular events (HR: 0.340; 95% CI: 0.124–0.933).

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Implication

Shows that severe coronary calcification and low matrix Gla protein increase cardiovascular risk in chronic kidney disease, highlighting their prognostic role.

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A 2021 study studied this question.

synapsesocial.com/papers/6a961f5474f460f8209fe994 https://doi.org/10.1080/0886022x.2021.1953529

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Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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