Effects of Aluminium Chloride Exposure on the Histology of the Liver of Adult Wistar Rats

Aluminium is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes. It presence has so heavily contaminated the environment that exposure to it is virtually inescapable. The liver is the largest gland of the body that processes blood and breaks down nutrients, drugs into forms that are easier to use for the rest of the body. This study was aimed at evaluating the possible effects that aluminium chloride exposure could have on the histology of the liver. Ten wistar rats were used and were divided into five groups; group I was the control, group II received 475mg kg -1 , group III received 950mgkg -1 , group IV received 1,425mg kg -1 and group V received 1,900mg kg -1 via oral intubation for duration of eight weeks. The liver tissues was fixed, processed, stained in H&E and slides viewed under light microscope. Our observations showed that aluminium chloride exposure was detrimental to the liver of wistar rats, as indicated by congested central vein and distorted sinusoids.