Synthetic study demonstrates ligand-promoted para-selective C–H olefination of benzoic acid derivatives, indicating a viable route to challenging para-substituted compounds.
Achieving high para -selective C–H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho -C–H bond. Herein, we report the ligand promoted high para -selective C–H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para -substituted benzoic acid derivatives.
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Shen et al. (2023) studied this question.
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