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July 19, 1985Science

Sequence Homology Between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

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Population

Decapeptides in two human myelin proteins and proteins of viruses known to infect humans

Design

Other

Authors

UJUlrike JahnkeThomson Reuters (United Kingdom)EFEdmond H. FischerUniversity of GenevaEAEllsworth C. AlvordKlinik und Poliklinik für Psychosomatik und Psychotherapie

Discussion

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Implication

May implicate molecular mimicry in post-infectious demyelination; leaves open validation in clinical cohorts.

Structured PICO

P
Population
Decapeptides in two human myelin proteins (myelin basic protein and P2 protein) and proteins of viruses known to infect humans (measles, Epstein-Barr, influenza A and B, and others)
I
Intervention
Computer searches for sequence homology
O
Outcome
Sequence homologies between viral proteins and myelin proteins

Sequence homologies between viral and myelin proteins suggest that immunological cross-reactions may be the mechanism underlying post-infectious or post-vaccinal demyelinating diseases.

Cite This Study

Jahnke et al. (1985) studied this question.

synapsesocial.com/papers/6a9623dbb425eb023f523df4https://doi.org/10.1126/science.2409602
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  4. 4Biological Activity and Synthesis of an Encephalitogenic Determinant1971 · 97 citations
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