Key result
While overall heart rate variability was comparable between groups, children with severe ADHD exhibited significantly lower parasympathetic activity and higher mean heart rates compared to healthy controls.
Why the study?
Is heart rate variability altered in children newly diagnosed with ADHD compared to healthy controls?
Case-Control (n=102)
No
Is heart rate variability altered in children newly diagnosed with ADHD compared to healthy controls?
Absolute Event Rate: 21% vs 24.4%
p-value: p=0.174
Severe ADHD in children is associated with altered heart rate variability, suggesting more overt autonomic nervous system dysfunction as disease severity increases.
Severe ADHD may link to autonomic changes via HRV; leaves open diagnostic or prognostic utility in children.
Objective: The aim of the present study was to evaluate heart rate variability (HRV) in children newly diagnosed as attention-deficit/hyperactivity disorder (ADHD). Methods: A total of 51 children with new ADHD diagnosis who were not received any treatment formed the study group and 51 age and sex-matched healthy children were en-rolled as the control group. 24-hour heart rate (HR) recordings were performed with rhythm Holter monitoring and HRV parameters indicating autonomous nervous system (ANS) functions were evaluated. Children in ADHD group were further divided into two groups as severe and mild ADHD according to Clinical Global Impressions-ADHD-Severity scale. Results: HRV parameters were comparable between ADHD and control groups. Whereas, percent-age of consecutive NN intervals over 50 msn (pNN50) and minimum Spectral Power per hour (minSPH) values were lower; while, maximum 1-hour heart rate Holter (maxHRH) and mean heart rate (HR) values were higher in severe ADHD group than those of control group. Conclusion: These results support that as the severity of ADHD increases, ANS dysfunction becomes more overt. Further large scale, multi-centered, randomized-controlled clinical trials are needed to clarify possible role of ANS dysfunction in ADHD etiopathogenesis.
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Yüksel et al. (2018) conducted a case-control in Attention-deficit/hyperactivity disorder (n=102). Attention-deficit/hyperactivity disorder vs. Healthy controls was evaluated on pNN50 (percentage of consecutive NN intervals over 50 ms) (p=0.174). While overall heart rate variability was comparable between groups, children with severe ADHD exhibited significantly lower parasympathetic activity and higher mean heart rates compared to healthy controls.
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