Key result
Three-dimensional cryo-electron microscopy revealed that the Ser-2808 phosphorylation site is 105-120 Å away from the FKBP12.6 binding site, indicating it is unlikely to directly disrupt binding.
Population
Cardiac ryanodine receptor (RyR2) and skeletal muscle RyR1 models
Design
Preclinical
Authors
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Questions direct Ser-2808 disruption of RyR2-FKBP12.6 binding in animals; leaves open alternative mechanisms and human relevance.
Cryo-electron microscopy mapping demonstrates that the Ser-2808 phosphorylation site is distant from the FKBP12.6 binding site on RyR2, challenging the hypothesis that hyperphosphorylation at this site directly disrupts binding.
Meng et al. (2007) studied this question. Three-dimensional cryo-electron microscopy mapping was evaluated on Three-dimensional location of the Ser-2808 phosphorylation site relative to the FKBP12.6 binding site. Three-dimensional cryo-electron microscopy revealed that the Ser-2808 phosphorylation site is 105-120 Å away from the FKBP12.6 binding site, indicating it is unlikely to directly disrupt binding.
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