Key result
Daily resveratrol treatment for 16 weeks did not improve inflammatory status or glucose homeostasis in men with metabolic syndrome, but 1000 mg/day significantly increased total cholesterol (P<0.002).
Why the study?
Does resveratrol improve inflammatory status and metabolic markers in middle-aged men with metabolic syndrome?
RCT (n=74)
double-blind
randomized
No
Does resveratrol improve inflammatory status and metabolic markers in middle-aged men with metabolic syndrome?
Resveratrol supplementation does not improve metabolic or inflammatory parameters in men with metabolic syndrome and may worsen lipid profiles at high doses.
No takes yet. Share an insight, caveat, or question.
High-dose resveratrol should be avoided in metabolic syndrome; challenges presumed anti-inflammatory and metabolic benefits.
Kjær et al. (2017) conducted an RCT in metabolic syndrome (n=74). Resveratrol vs. placebo was evaluated on Plasma levels of high-sensitivity C-reactive protein (hs-CRP), circulating lipids, and inflammatory markers in circulation and adipose/muscle tissue biopsy specimens; glucose metabolism; and body composition. Daily resveratrol treatment for 16 weeks did not improve inflammatory status or glucose homeostasis in men with metabolic syndrome, but 1000 mg/day significantly increased total cholesterol (P<0.002).
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