Efficient synthesis strategies by application of transition metal-catalyzed carbene/nitrene insertions into C–H bonds

Transition metal-catalyzed insertion of carbenes and nitrenes into C-H bonds has become a powerful tool for the construction of C-C and C-N bonds in the synthesis of complex natural products. In this Highlight, a selection of syntheses are detailed involving the implementation of C-H insertion reactions leading to strategies marked by improved efficiency.