Neurofascin-155 as a putative antigen in combined central and peripheral demyelination

Combined central and peripheral demyelination (CCPD) encompasses a wide array of disorders ranging from myeloradiculoneuritis and encephalomyeloradiculoneuritis, which often occur after infection or vaccination, to co-occurrence of multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).1,2 Acknowledgment: The authors thank Dr. Isabel Illa (Hospital de la Santa Creu I Sant Pau de Barcelona, Universitat Autònoma de Barcelona, Spain) for providing the control NF155-positive CIDP serum; Dr. Fabio Blandini (C. Mondino National Neurological Institute, IRCCS, Pavia, Italy) for providing the rat sciatic nerves; and Dr. Emilio Ciusani (IRCCS Foundation, C. Besta Neurological Institute, Milan, Italy) for contributing with CCPD sera collection.