Key result
A novel differential pulse voltammetry method using a boron-doped diamond electrode successfully quantified famciclovir in human serum with a limit of detection of 0.42 µM.
A differential pulse voltammetry method using a boron-doped diamond electrode was successfully developed for the sensitive detection of the antiviral drug famciclovir in human serum.
May aid famciclovir quantification; leaves open clinical validation and therapeutic monitoring.
The electrochemical oxidation of famciclovir was investigated in pH range 2.0-10.0 using differential pulse voltammetry at boron-doped diamond electrode. The experimental results from pH and scan rate studies showed that the oxidation behavior of famciclovir at boron doped diamond electrode was irreversible and diffusion-controlled. Also, by using differential pulse technique at electrode, the anodic peak current is obtained to be linear over the range of concentration 0.5 µM - 12 µM and 6 µM - 100 µM in pH 4.7 acetate buffer solution (ABS) for standard drug solution and human serum, respectively. Limits of detection were 0.022 µM and 0.42 µM for standard drug solution and human serum, respectively. The repeatability, reproducibility, selectivity, precision and accuracy of developed method in all media were investigated and calculated. This method was successfully applied for the analysis of famciclovir human serum samples.
No takes yet. Share an insight, caveat, or question.
Çiğdem Kanbeş Dindar (2022) studied Famciclovir quantification. Differential pulse voltammetry at boron-doped diamond electrode was evaluated on Limit of detection (LOD) for famciclovir in human serum. A novel differential pulse voltammetry method using a boron-doped diamond electrode successfully quantified famciclovir in human serum with a limit of detection of 0.42 µM.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: