Key result
Euphorbia supina extract supplementation significantly reduced body weight gain, epididymal white adipose tissue, and organ weights in high-fat-diet-induced obese mice.
Why the study?
Does Euphorbia supina extract reduce obesity and improve metabolic parameters in high-fat-diet-induced obese mice?
Does Euphorbia supina extract reduce obesity and improve metabolic parameters in high-fat-diet-induced obese mice?
Euphorbia supina extract demonstrates anti-obesity effects in a mouse model, potentially mediated by downregulation of PPARγ and C/EPBα.
Answers are grounded in this paper and cite their sources.
ESEE shows anti-obesity effects in obese mice; leaves open translation to human therapy.
The present study was undertaken to investigate the anti‑obesity effect of a 50% ethanol extract of Euphorbia supina (ESEE) in high‑fat‑diet (HFD)‑induced obese C57BL/6J mice. Mice were fed a HFD with or without ESEE (2, 10, or 50 mg/kg) or with Garcinia cambogia (positive control) for 6 weeks. ESEE supplementation significantly reduced body, epididymal white adipose tissue (eWAT), and organ weights (P<0.05). ESEE also reduced hepatic steatosis and improved serum lipid profiles. In addition, ESEE significantly reduced serum leptin levels and increased adiponectin levels, and significantly downregulated the mRNA and protein levels of proliferator‑activated receptor γ (PPARγ) and CCAAT/enhancer‑binding protein alpha (C/EPBα) in eWAT and liver tissues (all P<0.05). These results suggested that ESEE supplementation protects against HFD‑induced obesity by downregulating PPARγ and C/EPBα, and that ESEE may be beneficial for the prevention and treatment of obesity and associated diseases.
No takes yet. Share an insight, caveat, or question.
Nepali et al. (2018) studied High-fat-diet-induced obesity (n=36). Euphorbia supina extract (ESEE) vs. High-fat diet without ESEE was evaluated on Body weight gain (p=<0.05). Euphorbia supina extract supplementation significantly reduced body weight gain, epididymal white adipose tissue, and organ weights in high-fat-diet-induced obese mice.
Synapse has enriched 10 related papers. Consider them for comparative context: