Key result
Mice with the mini-muscle phenotype ran faster and further per day, with medial gastrocnemius muscles producing about half the mass-specific isotonic power and fatiguing at half the normal rate.
The mini muscle phenotype in selectively bred mice shifts the medial gastrocnemius toward a slower, more fatigue-resistant profile that supports increased aerobic running.
Supports mini-muscle mice as models for fatigue-resistant adaptations; leaves open translation to human endurance or cardiovascular performance.
As reported previously, artificial selection of house mice caused a 2.7-fold increase in voluntary wheel running of four replicate selected lines compared with four random-bred control lines. Two of the selected lines developed a high incidence of a small-muscle phenotype ("mini muscles") in the plantar flexor group of the hindlimb, which apparently results from a simple Mendelian recessive allele. At generations 36-38, we measured wheel running and key contractile characteristics of soleus and medial gastrocnemius muscles from normal and mini muscles in mice from these selected lines. Mice with mini muscles ran faster and a greater distance per day than normal individuals but not longer. As expected, in mini-muscle mice the medial and lateral gastrocnemius muscles were approximately 54 and 45% the mass of normal muscles, respectively, but the plantaris muscles were not different in mass and soleus muscles were actually 30% larger. In spite of the increased mass, contractile characteristics of the soleus were unchanged in any notable way between mini and normal mice. However, medial gastrocnemius muscles in mini mice were changed markedly toward a slower phenotype, having slower twitches; demonstrated a more curved force-velocity relationship; produced about half the mass-specific isotonic power, 20-50% of the mass-specific cyclic work and power (only 10-25% the absolute power if the loss in mass is considered); and fatigued at about half the rate of normal muscles. These changes would promote increased, aerobically supported running activity but may compromise activities that require high power, such as sprinting.
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Syme et al. (2005) studied Mini muscle phenotype in selectively bred mice. Mini muscle phenotype vs. Normal muscle phenotype was evaluated on Wheel running and key contractile characteristics of soleus and medial gastrocnemius muscles. Mice with the mini-muscle phenotype ran faster and further per day, with medial gastrocnemius muscles producing about half the mass-specific isotonic power and fatiguing at half the normal rate.
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