Annonaceous Acetogenins: The Hydroxyl Groups and THF Rings Are Crucial Structural Elements for Targeting the Mitochondria, Demonstration with the Synthesis of Fluorescent Squamocin Analogues

Track of acetogenins in living cells. Two fluorescent acetogenin probes have been prepared from natural squamocin to clearly demonstrate the crucial role of the polyoxygenated central part as a locus for mitochondria targeting. Reliable synthetic tools, such as radical decarboxylation and catalytic triazole formation, were exploited for the design of the molecules.