Why the study?
Does triiodothyronine improve postischemic left ventricular performance in isolated working rat hearts subjected to ischemia?
Population
Isolated working rat hearts receiving 20 mL of hyperkalemic NIH No. 1 cardioplegia and subjected to 20…
Comparison
Reperfusion with triiodothyronine-supplemented… vs Reperfusion with modified Krebs-Henseleit buffer…
Design
Preclinical
Authors
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May improve postischemic LV function in this model; leaves open clinical translation to human reperfusion injury.
Does triiodothyronine improve postischemic left ventricular performance in isolated working rat hearts subjected to ischemia?
In an isolated rat heart model of severe ischemia, triiodothyronine supplementation during reperfusion significantly improved left ventricular hemodynamic recovery without altering high-energy phosphate concentrations.
Holland et al. (1992) studied this question.
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