Cheap and clean! A novel Pd-catalyzed oxidative intramolecular chloroamination of unactivated alkenes has been developed by using hydrogen peroxide as an oxidant and CaCl2 as a chlorine source. A series of chlorinated piperidine derivatives has been obtained with high regio- and diastereoselectivities at room temperature (see scheme).
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Yin et al. (2011) studied this question.
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