Key result
Ultrasonic strain-rate imaging using the 'double peak sign' identified all 42 MRI late enhancement-positive fibrotic segments and predicted future fibrosis in Fabry disease patients.
Why the study?
Does ultrasonic strain-rate imaging accurately detect regional non-ischaemic fibrosis in hypertrophic myocardium compared to MRI late enhancement?
Population
40 subjects, including 30 patients with hypertrophic myocardium and 10 healthy controls.
Comparison
Ultrasonic strain-rate imaging to detect the… vs Magnetic resonance imaging using late enhancement
Design
Cohort
Follow-up
2 years (for follow-up MRI in a subset)
Authors
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May aid earlier fibrosis detection in Fabry cardiomyopathy; hypothesis-generating for replacing MRI late enhancement.
Observational (n=40)
Does ultrasonic strain-rate imaging accurately detect regional non-ischaemic fibrosis in hypertrophic myocardium compared to MRI late enhancement?
The 'double peak sign' on ultrasonic strain-rate imaging is a reliable tool for diagnosing regional non-ischaemic fibrosis in hypertrophic myocardium, potentially identifying fibrosis earlier than MRI late enhancement.
Weidemann et al. (2007) conducted an observational in Hypertrophic myocardium (n=40). Ultrasonic strain-rate imaging vs. Magnetic resonance imaging (MRI) late enhancement was evaluated on Detection of left ventricular fibrotic segments. Ultrasonic strain-rate imaging using the 'double peak sign' identified all 42 MRI late enhancement-positive fibrotic segments and predicted future fibrosis in Fabry disease patients.
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