Key result
Moderate to severe pulmonary valve regurgitation after pulmonary valve balloon dilatation was significantly associated with the development of transient left ventricle dysfunction in neonates.
Why the study?
The study aimed to identify echocardiographic predictors of transient left ventricle dysfunction following pulmonary valve balloon dilatation in neonates with pulmonary valve stenosis and atresia with intact septum at birth.
What are the echocardiographic predictors of transient left ventricle dysfunction after pulmonary valve balloon dilatation in neonates with pulmonary valve stenosis and atresia with intact septum?
Observational (n=29)
No
What are the echocardiographic predictors of transient left ventricle dysfunction after pulmonary valve balloon dilatation in neonates with pulmonary valve stenosis and atresia with intact septum?
p-value: p=<0.0001
Transient left ventricle dysfunction occurred in a subset of neonates following pulmonary valve balloon dilatation, accompanied by at least moderate pulmonary valve regurgitation.
Post-PVBD moderate-severe PR was associated with transient LV dysfunction; hypothesis-generating for risk stratification, needs prospective validation.
Background: The aim of this study is to identify echocardiographic predictors of transient left ventricle dysfunction after pulmonary valve balloon dilatation (PVBD), in neonates with pulmonary valve stenosis (PVS) and atresia with intact septum (PAIVS) at birth. Methods: The study includes patients admitted at the Bambino Gesù Children Hospital from January 2012 to January 2017. Clinical, echocardiographic and cardiac catheterization data before and after PVBD were retrospectively analyzed. Results: Twenty-nine infants were included in the study (21 male and eight female). The median age was 5.8 ± 7.1 days. Eight patients developed transient LV dysfunction (three PAIVS and five PVS) and comparing data before and after the procedure, there was no difference in right ventricle geometrical and functional parameters except for evidence of at least moderate pulmonary valve regurgitation after PVBD. Conclusion: < 0.05) in PVS and PAIVS patients.
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D’Anna et al. (2022) conducted an observational in Critical neonatal pulmonary stenosis and pulmonary atresia with intact ventricular septum (n=29). Moderate to severe pulmonary valve regurgitation vs. Mild or no pulmonary valve regurgitation was evaluated on Transient left ventricle dysfunction (p=<0.0001). Moderate to severe pulmonary valve regurgitation after pulmonary valve balloon dilatation was significantly associated with the development of transient left ventricle dysfunction in neonates.
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