famous botanist N~igeli n Zurich. In his letter, he sug-gested that sex determination might prove to be a phe-nomenon of heredity and segregation. But, as with his previous discovery of the principles of heredity, no at-tention was paid to his idea. Today, nobody doubts that genes control the sexual pathway. This is clear for systems with genetic sex de-termination, where inherited genetic differences dic-tate maleness or femaleness; it is less obvious, at least at first glance, for systems with environmental sex de-termination, where there are no genetic differences be-tween males and females. In the case of hermaphro-dites, however, where the same genotype differentiates male and female organs within an individual, we real-ize that sex determination and differentiation are a
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Nöthiger et al. (1985) studied this question.