Key result
Stimulation of U937 cells with endotoxin or PMA increased VIIa/TF inhibitor activity approximately 3-fold and 20-fold, respectively, with secretion persisting after cell surface TF declined.
Stimulation of U937 monocyte-like cells with endotoxin or PMA increases the secretion of VIIa/TF inhibitor, which persists even after cell surface TF declines.
No takes yet. Share an insight, caveat, or question.
In vitro monocyte data suggest regulated inhibitor release; leaves open in vivo role in human thrombosis.
Rana et al. (1988) studied Human monocytic tumor cell line U937. Endotoxin or phorbol myristate acetate (PMA) vs. Unstimulated cells was evaluated on Factor VIIa/tissue factor (VIIa/TF) inhibitor activity. Stimulation of U937 cells with endotoxin or PMA increased VIIa/TF inhibitor activity approximately 3-fold and 20-fold, respectively, with secretion persisting after cell surface TF declined.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: