Key result
Apixaban treatment significantly preserved the total number of intramyocardial arteries compared to untreated controls 3 days after experimental acute volume overload (12.0 vs 10.2 point score units, p=0.013).
Why the study?
Acute volume overload induces early ischemia-like changes in intramyocardial arteries, prompting investigation into whether the Factor Xa inhibitor apixaban interacts with the myocardium early after AVO.
Does apixaban interact with the myocardium early after acute volume overload in a rat model?
Does apixaban interact with the myocardium early after acute volume overload in a rat model?
In a rat model of acute volume overload, apixaban treatment was associated with increased myocardial arterial edema and elevated ANP and MMP9 expression, suggesting potential adverse myocardial interactions.
Apixaban alters intramyocardial arteries and ANP/MMP9 expression early after AVO in rats; leaves open relevance to human volume overload.
OBJECTIVE: Acute volume overload (AVO) induces early ischemia-like changes in intramyocardial arteries. We investigated whether the Factor Xa (FXa) inhibitor apixaban interacts with the myocardium early after AVO. METHODS: Fifty-five syngeneic Fisher rats underwent surgical abdominal aortocaval fistula to induce AVO. Among them, 17 rats were treated with apixaban (10 mg/kg/day). The myocardial outcome was studied using histological analysis and by measuring atrial natriuretic peptide (ANP) and matrix metalloprotease 9 (MMP9) gene expression. RESULTS: +apixaban (AVO+A) group compared with that in the AVO group (12.0 ± 1.2 and 10.2 ± 1.5, point score units, respectively). In the AVO+A group, there were significantly more edematous nuclei in myocardial arteries in the right and left ventricle compared with that in the AVO group. ANP and MMP9 expression levels continued to increase significantly in the AVO+A group compared with those in the AVO group. CONCLUSION: Apixaban interacts with intramyocardial arteries in the left and right ventricles after AVO and ANP and MMP9 expression levels increased. Thus, the myocardial effect of Factor Xa inhibition needs to be monitored after AVO.
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Huuskonen et al. (2022) studied Acute volume overload (n=58). Apixaban vs. Untreated acute volume overload was evaluated on Total number of intramyocardial arteries after 3 days (p=0.013). Apixaban treatment significantly preserved the total number of intramyocardial arteries compared to untreated controls 3 days after experimental acute volume overload (12.0 vs 10.2 point score units, p=0.013).
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