Key result
A soft biomimetic approach for preimplantation processing of glutaraldehyde-fixed biomaterials radically increased resistance to calcification by preserving the native extracellular matrix.
Why the study?
Pathological aseptic calcification commonly leads to premature failure of heart valve bioprostheses, and processing methods used to obtain glutaraldehyde-fixed pericardium-based biomaterials dictate their durability.
A soft biomimetic approach to processing GA-fixed pericardial tissue preserves the extracellular matrix and significantly improves resistance to calcification, potentially extending the durability of bioprosthetic heart valves.
Pathological aseptic calcification is the most common form of structural valvular degeneration (SVD), leading to premature failure of heart valve bioprostheses (BHVs). The processing methods used to obtain GA-fixed pericardium-based biomaterials determine the hemodynamic characteristics and durability of BHVs. This article presents a comparative study of the effects of several processing methods on the degree of damage to the ECM of GA-fixed pericardium-based biomaterials as well as on their biostability, biocompatibility, and resistance to calcification. Based on the assumption that preservation of the native ECM structure will enable the creation of calcinosis-resistant materials, this study provides a soft biomimetic approach for the manufacture of GA-fixed biomaterials using gentle decellularization and washing methods. It has been shown that the use of soft methods for preimplantation processing of materials, ensuring maximum preservation of the intactness of the pericardial ECM, radically increases the resistance of biomaterials to calcification. The data obtained are of interest for the development of new calcinosis-resistant biomaterials for the manufacture of BHVs.
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Zvyagina et al. (2023) studied Structural valvular degeneration and calcification of heart valve bioprostheses. Soft biomimetic approach (gentle decellularization and washing methods) vs. Standard processing methods was evaluated on Degree of damage to the extracellular matrix, biostability, biocompatibility, and resistance to calcification. A soft biomimetic approach for preimplantation processing of glutaraldehyde-fixed biomaterials radically increased resistance to calcification by preserving the native extracellular matrix.
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