Gender-differences in prevalence and outcome of ischemic stroke and promoting factors of atrial thrombi
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Key result
Female patients with ischemic stroke had a higher in-hospital case-fatality rate compared to males (9.4% vs. 7.1%), despite males having a higher overall incidence of ischemic stroke.
Why the study?
Are there gender-specific differences in the prevalence and outcome of ischemic stroke and promoting factors of atrial thrombi?
Population
Nationwide sample of inpatients with ischemic stroke and a retrospective cohort of 227 patients who…
Design
Cohort
Authors
Discussion
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Implication
Sex differences in stroke burden may inform targeted prevention; leaves open AF's causal role in female outcomes pending prospective studies.
Study Design
Type
Observational (n=292,396)
Multicenter
Yes
Structured PICO
Are there gender-specific differences in the prevalence and outcome of ischemic stroke and promoting factors of atrial thrombi?
P
Population
292,396 inpatients with ischemic stroke in Germany in 2015, analyzed to determine gender differences in incidence, atrial fibrillation prevalence, and in-hospital mortality.
C
Comparator
Male vs. female patients
O
Outcome
Incidence of ischemic stroke, case-fatality rate, and promoting factors of atrial thrombihard clinical
Main Result
Absolute Event Rate: 9.4% vs 7.1%
While ischemic stroke incidence is higher in males, females experience higher case-fatality rates, likely driven by a higher prevalence of atrial fibrillation.
Limitations
- Nationwide sample data are pooled/aggregated without statistical testing for difference with P-values or adjustment for age and comorbidities.
- Only patients treated in-hospital were included.
- Antithrombotic regimens were not reported.
- The TEE study was a single-center retrospective analysis of a medium-sized cohort without follow-up.
Cite This Study
Keller et al. (2018) conducted an observational in Ischemic stroke (n=292,396). Female sex vs. Male sex was evaluated on In-hospital case-fatality rate. Female patients with ischemic stroke had a higher in-hospital case-fatality rate compared to males (9.4% vs. 7.1%), despite males having a higher overall incidence of ischemic stroke.
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