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June 27, 2013Journal of NeuroinflammationOpen Access

Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system

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Key result

Genetic background significantly influenced susceptibility to TBEV infection, with resistant STS mice showing strong neutralizing antibody responses and lower brain cytokine production compared to highly susceptible CcS-11 mice.

Population

BALB/c-c-STS/A (CcS/Dem) recombinant congenic mouse strains (BALB/c, STS, and CcS-11 mice)

Comparison

Subcutaneous or intracerebral inoculation of TBE… vs Comparison between different mouse strains

Design

Preclinical

Authors

MPMartin PalusJVJarmila VojtíškováJSJiřı́ Salát

Discussion

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Overview

Supports genetic influences on TBEV outcomes in mice; hypothesis-generating for human susceptibility studies.

Structured PICO

P
Population
Female mice of different genetic backgrounds (BALB/c, STS, and CcS/Dem recombinant congenic strains) aged 12-15 weeks infected with TBEV to study disease susceptibility.
I
Intervention
Subcutaneous or intracerebral inoculation of TBE virus
C
Comparator
Comparison between different mouse strains (BALB/c, STS, and CcS-11)
O
Outcome
TBE virus growth, neutralizing antibody response, key cytokine and chemokine mRNA production, changes in mRNA levels of cell surface markers of immunocompetent cells in brain, and survivalsurrogate

Main Result

p-value: p=<0.05

Genetic background strongly influences the clinical course of TBE virus infection in mice, with neutralizing antibody response and cytokine/chemokine expression playing crucial roles in disease severity and survival.

Limitations

  • Animal models may not fully replicate human disease pathogenesis
  • Specific genes responsible for the phenotype in the recombinant congenic strains remain to be identified

Cite This Study

Palus et al. (2013) studied Tick-borne encephalitis virus (TBEV) infection. TBEV infection vs. Different mouse strains (STS vs CcS-11 vs BALB/c) was evaluated on Survival after subcutaneous inoculation of TBEV (p=<0.05). Genetic background significantly influenced susceptibility to TBEV infection, with resistant STS mice showing strong neutralizing antibody responses and lower brain cytokine production compared to highly susceptible CcS-11 mice.

synapsesocial.com/papers/6a9632b5d4400ecf0522fbbchttps://doi.org/10.1186/1742-2094-10-77
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Also Consider

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  2. 2Loci controlling lymphocyte production of interferon γ after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility2009 · 13 citations
  3. 3Immunomodulatory cytokines determine the outcome of Japanese encephalitis virus infection in mice2009 · 38 citations