Answers are grounded in this paper and cite their sources.
The hypervalent iodine reagent PIFA promotes the intramolecular electrophilic cyclization of easily accessible alkynylamides and alkynyl carboxylic acids, leading to the formation of pyrrolidinone and lactone skeletons, respectively, in a very efficient way. A synthetic study and a mechanistic proposal for these transformations are presented.
No takes yet. Share an insight, caveat, or question.
Tellitu et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: