Key result
Myocardial infarction patients had significantly higher plasma levels of D-dimer (471 vs 160) and mean platelet volume (8.8 vs 8.0), and lower platelet counts (268 vs 324) compared to healthy controls.
Why the study?
D-dimer was previously only used for venous thromboembolism and aortic dissection, prompting investigation into its significance alongside platelets and MPV in myocardial infarction.
Case-Control (n=100)
No
Absolute Event Rate: 471% vs 160%
p-value: p=0.001
Elevated D-dimer and MPV, along with decreased platelet count, are significantly associated with myocardial infarction and may serve as useful biomarkers for risk prediction and diagnosis.
Elevated D-dimer and MPV in this small Sudanese case-control study may support MI risk assessment; leaves open diagnostic utility pending larger validation.
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Ahmed et al. (2022) conducted a case-control in Myocardial infarction (n=100). Myocardial infarction vs. Healthy controls was evaluated on Plasma level of D-dimer (p=0.001). Myocardial infarction patients had significantly higher plasma levels of D-dimer (471 vs 160) and mean platelet volume (8.8 vs 8.0), and lower platelet counts (268 vs 324) compared to healthy controls.
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