Key result
In chick brain myosin V, the specific IQ motif responsible for calcium-induced dissociation of calmodulin was identified as IQ2, and essential light chains do not reside on IQ1 and IQ2.
Population
Chick brain myosin V (BMV)
Comparison
High calcium concentration vs Low calcium concentration
Design
Preclinical
Authors
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No immediate clinical implications; leaves open IQ2's role in mammalian cardiac myosin regulation.
This basic science study identifies IQ2 as the specific motif responsible for calcium-induced dissociation of calmodulin from chick brain myosin V.
Koide et al. (2006) studied this question. High Ca2+ concentration vs. Low Ca2+ concentration was evaluated on Identification of the specific IQ motif responsible for calcium-induced dissociation of CaM. In chick brain myosin V, the specific IQ motif responsible for calcium-induced dissociation of calmodulin was identified as IQ2, and essential light chains do not reside on IQ1 and IQ2.
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