Key result
Spontaneously hypertensive rats exhibit down-regulated neuronal and endothelial nitric oxide synthase, and up-regulated inducible nitric oxide synthase and neurotrophic factors in the carotid body.
Why the study?
Knowledge of the morphofunctional and neurochemical aspects of the carotid body is needed to improve understanding of respiratory and cardiovascular homeostasis in health and disease.
p-value: p=<0.001
Heightened chemosensory discharge from the carotid body due to impaired nitric oxide and enhanced neurotrophin signaling may contribute to sympathetic hyperactivity and systemic hypertension.
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Carotid body hyperactivity may sustain sympathetic hypertension; hypothesis-generating for glomus cell-targeted interventions pending human data.
Lazarov et al. (2019) conducted a review in Hypertension. Spontaneous hypertension vs. Normotensive state was evaluated on Expression of nitric oxide synthase isoforms and neurotrophic factors (p=<0.001). Spontaneously hypertensive rats exhibit down-regulated neuronal and endothelial nitric oxide synthase, and up-regulated inducible nitric oxide synthase and neurotrophic factors in the carotid body.
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